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赵海苹
女,37岁,医学博士,首都医科大学脑血管病研究室,副研究员。2009年毕业于中国协和医科大学,获得博士学位,同年进入北京大学医学部进行博士后工作,从事脑血管动脉粥样硬化炎症机制的研究,2011年进入宣武医院,从事脑缺血神经保护基础及转化医学的研究。先后主持国家自然科学基金青年项目1项、面上项目1项,参与3项国家自然科学基金。2013年获国际脑血流与脑代谢协会颁发的青年学者奖,2014年入选北京市科技新星计划,2015年获美国中风协会颁发的2014中风进步与创新奖。任副主编出版著作1部《脑血管病实验方法学》。共发表SCI论文45篇(Stroke, Exp Neurol, J Neuroimmune Pharmacol, FEBS Journal等杂志),核心期刊论文43篇。现任北京中西医结合学会神经内科专业委员会秘书长、中国老年医学学会脑血管病分会青年委员、北京神经内科学会转化医学专业委员会青年委员、中国中西医结合学会第六届微循环专业委员会青年委员。
论文专著 经历 研究方向
发表SCI论文45篇(第一作者、共同第一作者22篇,其他作者23篇)
1. Wang J*, Zhao H*, Fan Z, Li G, Ma Q, Tao Z, Wang R, Feng J#, Luo Y#. Diagnostic potential of lncRNA H19 in ischemic stroke: role of HDAC-dependent microglial proliferation and activation. stroke. Accept. IF=5.787
2. Wang R*, Li J, Duan Y, Tao Z, Zhao H#, Luo Y#. Effects of erythropoietin on gliogenesis during cerebral ischemic/reperfusion recovery in adult mice. Proof. IF=3.697
3. Zhao H*, Han Z, Zhang S, Li G, Luo Y#. Therapeutic opportunities and cellular targets of Panax notoginseng on prevention of senescence-associated diseases and disorders. Aging Dis. Review. Accept. IF=3.697
4. Wang J*, Cao B, Zhao H#, Feng J#. One of the most exalted herbal medicine in ancient China--Ganoderma lucidum: emerging roles in anti-aging. Aging Dis. Review. Proof. IF=3.697
5. Zhao H*, Liu P, Xu C, Gao L, Luo Y#. A unique MicroRNAs signature with Yang and Yin in acute ischemic stroke patients. Chin J Integr Med. Accept. IF=1.234
6. Zhao H*, Li G, Ma Q, Tao Z, Wang R, Fan Z, Yan F, Ji X, Luo Y#. MiR-99a-5p in circulating immune cells as novel potential biomarkers in hyperacute ischemic stroke. Brain Circulation. 2017, 3: 21-28.
7. Zhao H*, Han Z, Ji X, Luo Y. Epigenetic regulation of oxidative stress in ischemic stroke. Aging Dis. 2016, 7(3): 295-306. Review. IF=3.697
8. Wang R, Wu X, Liang J, Qi Z, Liu X, Min L, Ji X, Luo Y, Zhao H#. Intra-artery infusion of recombinant human erythropoietin reduces blood-brain barrier disruption in rats following cerebral ischemia and reperfusion. Int J Neurosci. 2015, 125(9):693-702. IF=1.717
9. Zhao H*, Wang R, Wu X, Liang J, Qi Z, Liu X, Min L, Ji X, Luo Y#. Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. J Neuroimmune Pharmacol. 2015, 10(1): 153-161. IF=3.896
10. Liu P*, Zhao H*, Wang R, Wang P, Tao Z, Gao L, Yan F, Liu X, Yu S, Ji X, Luo Y#. MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress. Stroke. 2015, 46(2): 513-519. IF=6.018
11. Tao Z*, Zhao H*, Wang R, Liu P, Yan F, Zhang C, Ji X, Luo Y#. Neuroprotective effect of microRNA-99a against focal cerebral ischemia reperfusion injury in mice. J Neurol Sci. 2015, 355(1-2): 113-119. IF=2.474
12. Zhao H*, Wang R, Tao Z, Gao L, Yan F, Gao Z, Liu X, Ji X, Luo Y#. Ischemic postconditioning relieves cerebral ischemia and reperfusion injury through activating activating T-LAK Cell-Originated Protein Kinase/Protein Kinase B Pathway in Rats. Stroke. 2014, 45(8): 2417-2424. IF=6.018
13. Zhao H*, Wang R, Tao Z, Yan F, Gao L, Liu X, Min L, Jia Y, Ji X, Luo Y#. Activation of T-LAK-cell-originated protein kinase mediated antioxidation protects against focal cerebral ischemia-reperfusion injury. FEBS Journal. 2014, 281(19): 4411-4420. IF=4.237
14. Zhao H*, Tao Z, Wang R, Liu P, Gao L, Ji X, Luo Y#. MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion. Brain research. 2014, 1592: 65-72. IF=2.828
15. Wu XN*, Zhao H*, Min L, Zhang C, Liu P, Luo Y#. Effects of 2-Deoxyglucose on ischemic brain injuries in rats. Int J Neurosci. 2014, 124(9): 666-672. IF= 1.717
16. Song J*, Zhao H*, Liu P, Li N, Huang L, Wang P, Gao L, Luo Y#. Chinese Herbal Formula Qi-Lian-Gui-Shou Tang protects against acute ischemic cerebral injury in rats. Eur J Integr Med. 2014, 6(3): 286-293. IF= 0.769
17. Zhao H*, Wang J*, Gao L, Wang R, Liu X, Gao Z, Tao Z, Xu C, Song J, Ji X, Luo Y#. MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. Stroke. 2013, 44(6): 1706-1713. IF=5.729
18. Zhao H*, Luo Y*, Liu X, Wang R, Yan F, Li S, Leak RK, Ji X#. Ischemic post-conditioning partially reverses cell cycle reactivity following ischemia/reperfusion injury: a genome-wide survey. CNS Neurol Disord Drug Targets. 2013, 12(3): 350-359. IF=3.81
19. Zhao H*, Feng J*, Sun K, Liu Y, Wei X, Fan J, Huang P, Mao X, Zhou Z, Wang C, Wang X#, Han J#. Caffeic acid inhibits acute hyperhomocysteinemia-induced leukocyte rolling and adhesion in mouse cerebral venules. Microcirculation. 2012, 19 (3): 233-244. IF=2.763
20. Gao L*, Zhao H*, Liu Q, Song J, Xu C, Liu P, Gong W, Wang R, Liu K#, Luo Y#. Improvement of hematoma absorption and neurological function in patients with acute intracerebral hemorrhage treated with Xueshuantong. J Neurol Sci. 2012, 323(1-2): 236-240. IF=2.353
21. Zhao H*, Lv D, Zhang W, Dong W, Feng J, Xiang Z, Huang L, Qin C#, Zhang L#. Ginsenoside-Rb1 attenuates dilated cardiomyopathy in cTnTR141W transgenic mouse. J Pharmacol Sci. 2010, 112 (2): 214-222. IF=2.15
22. Zhao H*, Lv D, Zhang W, Zhang L, Wang S, Ma C, Qin C#, Zhang L#. Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnTR141W transgenic mice. Acta Pharmacol Sin. 2010, 31(3): 281-288. IF=3.166
23. Han Z*, Zhao H, Wang R, Tao Z, Fan Z, Luo Y, Luo Y#, Ji X#. TOPK inhibit neuronal injury by positively regulates microglia M2 polarization through directly inhibiting HDAC activity. Aging Dis. Proof. IF=3.697
24. Wang R*, Zhao H, Li J, Duan Y, Tao Z, Luo Y#. Effects of Erythropoietin on white matter injury post-ischemic recovery in mice. Neurol Res. 2017, 39(6): 545-551. IF=1.418
25. Ma QF, Zhao H, Tao Z, Wang R, Liu P, Han Z, Ma S, Luo Y, Jia J. MicroRNA-181c exacerbates brain injury in acute ischemic stroke. Aging Dis. 2016, 7(6): 705-714. IF=3.697
26. Zhao Y, Fang Y, Li J, Duan Y, Zhao H, Gao L, Luo Y. Neuroprotective effects of Chrysophanol against inflammatory in middle cerebral artery occlusion mice. Neuroscience Letter. 2016, 630: 16-22. IF=2.107,
27. Wang R, Wu X, Zhao H, Min L, Tao Z, Ji X, Luo Y. Effects of Erythropoietin combined with tissue plasminogen activator on the rats following cerebral ischemia and reperfusion. Brain Circulation. 2016, 2(1): 54-60.
28. Ma SB, Zhao H, Ji X, Luo Y. Peripheral to central: organ interactions in stroke pathophysiology. Exp Neurol. 2015, 272C: 41-49. review IF=4.617
29. Wang N, Wang L, Zhao H, Liu P, Zhang C, Wang R, Gao L, Luo Y. Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats. Evid Based Complement Alternat Med. 2015, 2015:369021. IF=1.931
30. Liu X, Zhao S, Liu F, Kang J, Xia A, Li F, Zhang C, Zhao H, Yan F, Luo M, Luo Y, Ji X. Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis. Transl Stroke Res. 2014, 5(6): 692-700. IF=4.503
31. Liu P, Liu X, Akf Liou EY, Xing J, Jing Z, Ji X, Liu X, Zhao H, Yan F, Chen J, Cao G, Luo Y. The neuroprotective mechanism of erythropoietin-TAT fusion protein against neurodegeneration from ischemic brain injury. CNS Neurol Disord Drug Targets. 2014, 13(8): 1465-1474. IF=2.702
32. Liu P, Gao L, Song JX, Zhao H, Wu X, Xu C, Huang L, Wang P, Luo Y. A pilot study on the correlation of tongue manifestation with the site of cerebral infarction in patients with stroke. Chin J Integr Med. 2014, 20(11): 818-822. IF=1.401
33. Liu P, Gao L, Song J, Zhao H, Wu X, Huang L, Wang P, Luo Y. Correlation between tongue manifestations and glucose, total cholesterol, and high-density lipoprotein cholesterol in patients with acute cerebral infarction. J Tradit Chin Med. 2014, 34(2): 162-165. IF=1.023
34. Wu X, Min L, Cong L, Jia Y, Zhao H, Liu P, Luo Y. Sex differences in health-related quality of life among adult stroke patients in Northeastern China. J Clin Neurosci. 2014, 21(6): 957-961. IF= 1.387
35. Liu X, Li F, Zhao S, Luo Y, Kang J, Zhao H, Yan F, Li S, Ji X. MicroRNA-124-mediated regulation of inhibitory member of apoptosis stimulating protein of p53 family in experimental stroke. Stroke. 2013, 44(7): 1973-1980. IF=6.158
36. Leak RK, Zhang L, Luo YM, Li P, Zhao H, Liu X, Ling F, Jia J, Chen J, Ji X. Peroxiredoxin 2 battles poly (ADP-Ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury. Stroke. 2013, 44(4): 1124-1134. IF=5.729
37. Wang J, Tang Y, Zhang W, Zhao H, Wang R, Yan Y, Xu L, Li P. Insulin-like growth factor-1 secreted by brain microvascular endothelial cells attenuates neuron injury upon ischemia. FEBS Journal. 2013, 280(15): 3658-68. IF=4.25
38. Tang D, Zhao H, Pan C, Liu Y, Wei X, Yang X, Chen Y, Fan J, Wang C, Han J, Li P. QiShenYiQi Pills, a Compound Chinese Medicine, ameliorates doxorubicin-induced myocardial structure damage and cardiac dysfunction in rats. Evid Based Complement Alternat Med. 2013, 2013: 480597. IF=2.175
39. Min L, Shao S, Wu X, Cong L, Liu P, Zhao H, Luo Y. Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke. Neural Regen Res. 2013, 8(23): 2144-2154. IF=0.968
40. Qi Z, Luo Y, Liu X, Wang R, Zhao H, Yan F, Song Z, Luo M, Ji X. AKT/GSK3β-dependent autophagy contributes to neuroprotection of limb remote ischemic post-conditioning in transient cerebral ischemic rat model. CNS Neurosci Ther. 2012, 28(11): 965-973. IF=4.458
41. Hou J, Wang J, Zhang P, Li D, Zhang C, Zhao H, Fu J, Wang B, Liu J. Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprivation challenged rat microglial cells by inhibiting TLR4 signaling pathway. Int Immunopharmacol. 2012, 14(4): 749-757. IF=2.551
42. Wang J, Lei H, Li P, Han L, Hou J, Yan Y, Zhao H, Tomoko Tsuji. The anti-brain ageing effects of krill phosphatidylserine in SAMP10 mice. J Agric Sci. 2012, 4(9): 196-208. IF=2.076
43. Gao L, Liu P, Song J, Liu Q, Xu C, Huang L, Wang P, Zhao H, Luo Y. Study on the correlation of tongue manifestation with fibrinogen and neutrophil in acute cerebral infarction patients. Chin J Integr Med. 2012, 18(12): 942-945. IF=1.401
44. Liu X, Luo M, Yan F, Zhang C, Li S, Zhao H, Ji X, Luo Y. Ischemic postconditioning diminishes matrix metalloproteinase 9 expression and attenuates loss of the extracellular matrix proteins in rat brain injuries following middle cerebral artery occlusion and reperfusion. CNS Neurosci Ther. 2012, 18(10): 855-863. IF=4.458
45. Wang J, Yuan Z, Zhao H, Ju D, Chen Y, Chen X, Zhang J. Ferulic acid promotes endothelial cells proliferation through up-regulating cyclin D1 and VEGF. J Ethnopharmacol. 2011, 137 (2): 992-997. IF=3.055