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人员介绍
任长虹
女，首都医科大学宣武医院低氧医学研究所，副研究员。1999年4月至2004年3月就读于日本山形大学医学部神经病学专业，获得博士学位。2004年3月至2010年6月，先后在日本东京大学及军事医学科学院从事博士后研究工作。2010年8月起在首都医科大学宣武医院工作，2013年11月至2015年5月在美国北德克萨斯大学健康科学中心做访问学者。现任中华中医药学会中药调剂与合理用药分会常委，中国老年医学学会脑血管病分会青年委员会委员，中华医学会高原医学分会青年委员会委员。《Brain Circulation》杂志编委，《Plos One》，《Neruological Research》等SCI杂志审稿人。主持国家自然科学基金项目3项，省部级项目多项。目前发表SCI论文期刊论文30余篇，统计源期刊40余篇，申请专利2项。
论文专著 经历 研究方向
发表论文(近5年)
1. Li S, Hafeez A, Noorulla F, Geng X, Shao G, Ren C, Lu G, Zhao H, Ding Y, Ji X. Preconditioning in neuroprotection: From hypoxia to ischemia. Prog Neurobiol. 2017 Jan 18. pii: S0301-0082(15)30071-X. doi: 10.1016/j.pneurobio.2017.01.001
2. Li X,Ren, C, Li S, Han R, et al. Limb Remote Ischemic Conditioning Promotes Myelination by Upregulating PTEN/Akt/mTOR Signaling Activities after Chronic Cerebral Hypoperfusion. Aging and Disease. DOI: 10.14336/AD.2016.1227.
3. Ren C，Hang R, Shi J, Ji X, Ischemic stroke pathophysiology and cell therapy. (Springer Nature Singapore Pte Ltd. 2017 1 K. Jin，X Ji，Q, Zhuge，et al. (eds.), Bone marrow stem cell therapy for stroke, DOI 10.1007/978-981-10-2929-5_1)
4. Ren C, Li S, Wang B, Han R, Li N, Gao J, Li X, Jin K, Ji X. Limb remote ischemic conditioning increases Notch signaling activity and promotes arteriogenesis in the ischemic rat brain. Behav Brain Res. 2016 Oct 22. pii: S0166-4328(16)30901-9
5. Ren C, Sy C, Gao J, Ding Y, Ji X. Animal Stroke Model: Ischemia-Reperfusion and Intracerebral Hemorrhage. Methods Mol Biol. 2016;1462:373-90. doi: 10.1007/978-1-4939-3816-2_21
6. Ren C, Kobeissy F, Alawieh A, Li N, Li N, Zibara K, Zoltewicz S, Guingab-Cagmat J, Lamer SF, Ding Y, Hayes RL, Ji X, Mondello S. Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients. Scientific Rep. 2016, 6:24588.
7. Ren C, Liu K, Li N, Cui X, Gao Jin, Ji X, Ding Y. Neural transmission pathways are involved in the neuroprotection induced by post but not per-ischemic limb remote conditioning. Brain Circulation. 2015, 1(2):160-167.
8. Ren C, Li N, Wang B, Yang Y, Gao J, Li S, Jin K, Ji X. Limb ischemic perconditioning attenuates blood-brain barrier disruption and brain edema by inhibiting MMP-9 activity and occludin degradation after focal cerebral ischemia. Aging and Disease,2015,6(6):406-417.
9. Ren C, Wang P, Wang B, Li N, Li W, Zhang C, Jin K, Ji X. Limb remote ischemic per-conditioning in combination with post-conditioning reduces brain damage and promotes neuroglobin expression in the rat brain after ischemic stroke. Restor Neurol Neurosci, 2015. 33 (3) 369–379.
10. 任长虹，李宁. 基于当归芍药散的中医复方研究思路探析. 中医药学报. 2015, 43(1):4-6.
11. Ren C, Brian W, Li Ning, Jin K, Ji X*, Herbal formula Danggui-Shaoyao-San promotes neurogenesis and angiogenesis in rat following middle cerebral artery occlusion. Aging and Disease. 2015, 6(4):245-53
12. Ren C#, Guingab-Cagmat J#, Kobeissy F, Zoltewicz S, Mondello S, Gao M, Hafeez A, Li N, Geng X, Larner SF, Anagli J, Hayes RL, Ji X, Ding Y. A neuroproteomic and systems biology analysis of rat brain post intracerebral hemorrhagic stroke. Brain Res Bull. 2014,102:46-56.
13. Ren C#, Zoltewicz S#, Guingab-Cagmat J, Anagli J, Gao M, Hafeez A, Li N, Cao J, Geng X, Kobeissy F, Mondello S, Larner SF, Hayes RL, Ji X, Ding Y. Different expression of ubiquitin C-terminal hydrolase-L1 and αII-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis. Brain Res. 2013,1540:84-91.
14. Ren C#, Li Y#, Han R#, Gao D, Li W, Shi J, Hoogewijs D, Braeckman BP, De Henau S, Lu Y, Qu W, Gao Y, Wu Y, Li Z, Liu H, Wang Z, Zhang C*.GLB-13 is associated with oxidative stress resistance in Caenorhabditis elegans. IUBMB Life. 2013,65(5):423-434
15. Wu X, Ren C, Zhou H, Zhang L, Juan C, Yang Y*. Therapeutic effect of Zeng Ye decoction on primary Sjögren's syndrome via upregulation of aquaporin‑1 and aquaporin‑5 expression levels.
Mol Med Rep. 2014,10(1):429-434.
16. Zhang X, Jizhang Y, Xu X, Kwiecien TD, Li N, Zhang Y, Ji X, Ren C(通讯)* , Ding Y. Protective effects of remote ischemic conditioning against ischemia/reperfusion-induced retinal injury in rats. Vis Neurosci. 2014,31(3):245-252.
17. Ren C, Gao M, Dornbos D 3rd, Ding Y, Zeng X, Luo Y, Ji X. Remote ischemic post-conditioning reduced brain damage in experimental ischemia/reperfusion injury.Neurol Res. 2011 Jun;33(5):514-9
18. 宋海庆，李宁，张安波，任长虹(通讯)*. 肢体远隔缺血适应对大鼠缺血再灌注后脑水肿的影响中风与神经疾病杂志. 2015, 8:676-679.
19. 任长虹，杨勇，吴晓丹，吉训明*，孙丽英. 参附注射液对缺血性卒中大鼠血脑屏障的影响. 中医药学报. 2012,10(40):76-79.
20. Zhang Y, Ying G, Ren C, Jizhang Y, Brogan D, Liu Z, Li S, Ding Y, Borlongan CV, Zhang J, Ji X.Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke. Brain Res. 2015,1594:267-273.
21. Mouhieddine TH, Itani MM, Nokkari A, Ren C, Daoud G, Zeidan A, Mondello S, Kobeissy FH*. Nanotheragnostic applications for ischemic and hemorrhagic strokes: improved delivery for a better prognosis. Curr Neurol Neurosci Rep. 2015,15(1):505.
22. Geng X, Ren C, Wang T, Fu P, Luo Y, Liu X, Yan F, Ling F, Jia J, Du H, Ji X*, Ding Y. Effect of remote ischemic postconditioning on an intracerebral hemorrhage stroke model in rats. Neurol Res. 2012,34(2):143-148.
23. Zeng X#, Asmaro K#, Ren C#, Gao M, Peng C, Ding JY, Fredrickson V, Ji X,* Ding Y. Acute ethanol treatment reduces blood-brain barrier dysfunction following ischemia/reperfusion injury. Brain Res. 2012,1437:127-133.
24. Jiang B#, Ren C#, Li Y#, Lu Y, Li W, Wu Y, Gao Y, Ratcliffe PJ, Liu H, Zhang C*. Sodium sulfite is a potential hypoxia inducer that mimics hypoxic stress in Caenorhabditis elegans. J Biol Inorg Chem. 2011,16(2):267-274.
25. Li H#, Ren C#, Shi J#, Hang X, Zhang F, Gao Y, Wu Y, Xu L, Chen C, Zhang C*. A proteomic view of Caenorhabditis elegans caused by short-term hypoxic stress. Proteome Sci. 2010,8(1):49.
26. Qu W, Ren C, Li Y, Shi J, Zhang J, Wang X, Hang X, Lu Y, Zhao D and Zhang C*. Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens. BMC Genomics, 2011,12(1):170.
27. Wu Y, Ren C, Gao Y, Hou B, Chen T, Zhang C*. A novel method for promoting heterologous protein expression in Escherichia coli by fusion with the HIV-1 TAT core domain. Amino Acids. 2010,39(3):811-20.
28. Li W, Wu Y, Ren C, Lu Y, Gao Y, Zheng X, Zhang C*. The activity of recombinant human neuroglobin as an antioxidant and free radical scavenger. Proteins. 2011,79(1):115-125.
29. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, Li G, Ren C, Luo Y, Ling F, Jia J, Hua Y, Wang X, Ding Y, Lo EH, Ji X*.Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis.Neurology. 2012, 79(18):1853-1861.
30. 任长虹，高明清，李宁，吉训明. 脑卒中生物标记物研究的重要性及研究现状. 军事医学. 2012, 36(2):150-153 .
31. 任长虹，高明清，曹金强，李宁，吉训明. 大鼠脑脊液抽取的新方法.实验动物科学. 2012,29(1):61-62 .
32. 张迪，任长虹，吉训明，朱榆红. 脑缺血-再灌注损伤后的炎性反应过程及机制的研究进展.中国脑血管病杂志.2013，10(7):383-387.
33. 李馨蕊，任长虹，吉训明，韩剑虹. 远隔缺血预适应脑保护的实施方式及其机制的研究进展.中国脑血管病杂志. 2014, 10(5):265-269.
34. 崔潇文，任长虹，吉训明，李宁，高志峰，曾现伟. 远隔肢体缺血后适应对大鼠 MCAO 模型血管重塑的影响.潍坊医学院学报. 2014,4:257-259.
35. 侯宝军，任长虹，李思颉，曾现伟，季泰令，吉训明. 远程缺血预适应研究进展. 中国医药. 2013, 8(6): 2013,8(6):871-873.
36. 李娜，任长虹， 孙菲，李宁，吉训明. 脑梗死急性期患者血浆纤维蛋白原和D-二聚体及抗凝血酶Ⅲ水平的变化. 中国脑血管病杂志.2013, 10(5):268-272.
37. 王鹏成，任长虹，季泰令，吉训明. 缺血性卒中后血管新生的研究进展.中国脑血管病杂志. 2014, 6:325-328.
38. 马林林，任长虹，李宁，吉训明，曾现伟. 两种远隔缺血期适应的脑保护作用对比研究. 中国现代神经疾病杂志. 2013,13(4):313-317.
39. 马林林，任长虹，吉训明. 调节性T细胞对缺血再灌注器官的保护作用.临床医师杂志. 2012，6(23):7720-7722.
40. 李国青， 任长虹，孟然，吉训明. 慢性脑缺血致脑损伤的机制及治疗研究进展. 中华老年心血管病杂志. 2012，14(5):554-556.
41. 李国青，任长虹，孟然，吉训明. 神经胶质细胞与慢性脑缺血致脑白质损伤的相关性研究进展.2013,8(1):130-131.
42. 高明清，任长虹，吕翠，吉训明，曾现伟. 远隔缺血后适应减轻大脑缺血再灌注损伤. 中国卫生检验杂志. 2012, 8:312-314.
43. 曹金强，任长虹，吉训明. 远隔缺血后适应实施方案及机制研究进展. 临床医师杂志. 2012，6(9)：121-123.
44. 曹金强，周冀英，任长虹，吉训明. 重复肢体缺血再灌注对人体中心动脉压的影响，中国老年学杂志，2012，21(32): 4611-4613.
45. 李爱松，李婧，任长虹，吉训明，朱榆红. 动脉粥样硬化相关基因与缺血性卒中的相关性研究进展. 国际神经病学神经外科学杂志，2011，38(5):477-481.
46. 李婧，李爱松，任长虹，吉训明，朱榆红. 亚甲基四氢叶酸还原酶的基因多态性与缺血性脑血管病的关系. 国际神经病学神经外科学杂志，2012, 38(6):527-531.
