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人员介绍
戚智锋
神经生物学博士,副研究员,一直从事神经科学领域的研究工作,包括脑缺血/低氧性损伤 和预适应形成的分子机制和信号网络、线粒体氧化应激损伤的研究,熟悉脑缺血损伤领域的分子生物学实验手段。目前主要的研究方向为缺血性脑血管病的脑保护机制、微血管损伤以及线粒体损伤的基础和应用基础研究。承担多项国家级、北京市科研项目和人才项目，迄今为止发表SCI文章20余篇。多次在国际学术会议上做报告.
教育经历
1995.08-2000.07 山东医科大学 临床医学 医学学士
2004.08-2007.07 首都医科大学 神经生物学 理学硕士
2008.08-2011.07 首都医科大学 神经生物学 理学博士
工作经历
2000.12-2002.09 北京石景山医院内科 内科住院医师/执业医师
2011.08-2014.10 首都医科大学宣武医院脑损伤与保护实验室 实习研究员
2014.11-2016.11 首都医科大学宣武医院脑损伤与保护实验室 助理研究员
2015.03-2016.03 美国新墨西哥大学药学院\脑影像研究中心 访问学者博士后
2016.12-今 首都医科大学宣武医院脑损伤与保护实验室 副研究员
论文专著 经历 研究方向
发表文章
1. Qi Z(戚智锋), Bu X, Huang P, Zhang N, Han S, Fang L, Li J: Increased membrane/nuclear translocation and phosphorylation of p90 KD ribosomal S6 kinase in the brain of hypoxic preconditioned mice. Neurochemical Research 2007;32(9):1450-1459.
2. Huang P, Qi Z(戚智锋), Bu X, Zhang N, Han S, Fang L, Li J: Neuron-specific phosphorylation of mitogen- and stress-activated protein kinase-1 involved in cerebral hypoxic preconditioning of mice. Journal of Neuroscience Research 2007;85:1279-1287.
3. Bu X, Huang P, Qi Z(戚智锋), Zhang N, Han S, Fang L, Li J: Cell type-specific activation of p38 MAPK in the brain regions of hypoxic preconditioned mice. Neurochemistry International 2007;51:459-466.
4. Qi Z(戚智锋), Liu Y, Yang W, Cui T, Gao H, Duan C, Lu L, Zhao C, Zhao H, Yang H: Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochemistry International 2011;59(5):572-581.
5. Cui T, Fan C, Gu L, Gao H, Liu Q, Zhang T, Qi Z(戚智锋), Zhao C, Zhao H, Cai Q, Yang H: Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells. Brain Research 2011;1394:1-13.
6. Qi ZF(戚智锋，共同第一作者), Luo YM, Liu XR, Wang RL, Zhao HP, Yan F, Song ZJ, Luo M, Ji XM: AKT/GSK3beta-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model. CNS Neuroscience & Therapeutics 2012; 18(12):965-973.
7. Gao H, Yang W, Qi Z(戚智锋), Lu L, Duan C, Zhao C, Yang H: DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. Journal of Molecular Biology 2012;423:232-248.
8. Qi Z(戚智锋), Liu W, Luo Y, Ji X, Liu KJ: Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke. Medical Gas Research 2013; 1(3):2
9. Qi Z(戚智锋), Yan F, Shi W, Zhang C, Dong W, Zhao Y, Shen J, Ji X, Liu KJ, Luo Y. AKT-related autophagy contributes to the neuroprotective efficacy of Hydroxysafflor Yellow A against ischemic stroke in rats. Translational Stroke Research. 2014;5(4):501-509 .
10. Chen F, Qi Z(戚智锋,共同第一作者), Luo Y, Hinchliffe T, Ding G Xia Y, Ji X. Non-pharmaceutical therapies for stroke: mechanisms and clinical implications. Progress in Neurobiology 2014; 115(4): 246-269.
11. Li YN, Pan R, Qin XJ, Yang WL, Qi Z(戚智锋), Liu W, Liu KJ. Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression. Journal of Neurochemistry. 2014; 129(1): 120-129.
12. Zhao Y, Pan R, Li S, Luo Y, Yan F, Yin J, Qi Z(戚智锋), Yan Y, Ji X, Liu KJ. Chelating intracellularly accumulated zinc decreased ischemic brain injury through reducing neuronal apoptotic death. Stroke. 2014; 45(4) :1139-1147.
13. Liu Y, Sun Z, Sun S, Duan Y, Shi J, Qi Z(戚智锋), Meng R, Sun Y, Zeng X, Chui D, Ji X. Effects of hypoxic preconditioning on synaptic ultrastructure in mice. Synapse. 2015; 69(1):7-14.
14. Wang R, Wu X, Liang J, Qi Z(戚智锋), Liu X, Min L, Ji X, Luo Y, Zhao H. Intra-artery infusion of recombinant human erythropoietin reduces blood-brain barrier disruption in rats following cerebral ischemia and reperfusion. The International Journal of Neuroscience. 2015; 125(9):693-702
15. Zhao H, Wang R, Wu X, Liang J, Qi Z(戚智锋), Liu X, Min L, Ji X, Luo Y. Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. Journal of Neuroimmune Pharmacology. 2015;10(1):153-61.
16. Qi Z(戚智锋), Dong W, Shi W, Wang R, Zhang C, Zhao Y, Ji X, Liu KJ , Luo Y. Bcl-2 Phosphorylation Triggers Autophagy Switch and Reduces Mitochondrial Damage in Limb Remote Ischemic Conditioned Rats After Ischemic Stroke. Translational Stroke Research. 2015; 6:198–206.
17. Liang J, Qi Z (戚智锋,共同第一作者), Liu W, Wang P, Shi W, Dong W, Ji X, Luo Y, Liu KJ, Normobaric hyperoxia slows ischemic BBB damage and expands the therapeutic time window for tPA treatment in focal cerebral ischemia, Stroke, 2015, 46: 1344-1351.
18. Dong W, Qi Z(戚智锋, 共同通讯作者), Liang J, Shi W, Zhao Y, Luo Y, Ji X, Liu KJ, Reduction of zinc accumulation in mitochondria contributes to decreased cerebral ischemic injury by normobaric hyperoxia treatment in an experimental stroke model, Experimental Neurology, 2015, 272:181-189.
19. Shi S, Qi Z(戚智锋), Luo Y, Ji X, Liu KJ, Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective, Medical Gas Research, 2016;6(3),147-153.
20. Qi Z(戚智锋,共同第一作者), Liang J, Pan R, Dong W, Shen J, Yang Y, ZhaoY, Shi W, Luo Y, Ji X, Liu KJ, Zinc contributes to acute cerebral ischemia-induced blood-brain barrier disruption, Neurobiology of Disease, 2016, 95:12-21.
21. Qi Z(戚智锋), Liu KJ, Pathophysiological role of zinc in brain ischemia, Oncotarget 2017;8(4),5670-5671.
22. 戚智锋，韩松，李俊发。低氧预适应鼠脑内核糖体S6激酶磷酸化水平和蛋白表达量的变化。神经解剖学杂志2007 23 (2) 159-163
23. 戚智锋, 罗玉敏, 刘克建: 自由基和基质金属蛋白酶介导脑缺血血脑屏障损伤的研究进展. 生物物理学报 2012 , 28 (5) 383-391.
24. 戚智锋, 师文娟, 闫峰, 张晨诚, 刘克建, 罗玉敏. 羟基红花黄色素A对脑缺血再灌注大鼠星型胶质细胞活性的影响.中国脑血管病杂志,2013;10(9)488-491
25. 戚智锋, 师文娟, 闫峰, 罗玉敏, 刘克建. 羟基红花黄色素A对脑缺血再灌注大鼠MMP-9和claudin-5蛋白水平的影响. 首都医科大学学报. 2013; 34(6) 879-884.
26. 师文娟，梁佳，董雯，戚智锋，刘克建. 常压高浓度氧治疗对脑缺血-再灌注大鼠星形胶质细胞活性的影响. 首都医科大学学报，2015, 36(5): 709-13.
参编书目
2008年 细胞信号转导研究技术 中国协和医科大学出版社 编委
2014年 脑血管病实验方法学 中国医药科技出版社 编委
