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人员介绍

耿晓坤
副主任医师、副教授、硕士生导师。现任首都医科大学附属北京潞河医院神经内科行政副主任、潞河医院神经介入中心主任、卒中中心主任、环境医学研究所所长、中美神经科学研究所常务副所长、国自然基金评审专家、北京神经内科学会常务理事、青年委员会主任委员、北京神经内科学会介入分会副主委、中国卒中学会神经介入分会青年委员、中国老年医学学会脑血管病分会青年委员、美国韦恩州立大学客座教授。同时任《Neurological Research》和《中国卒中杂志》客座主编,及《Current Opinions in Neurological Science》、《Environmental Disease》和《Brain Circulation》杂志编委。
论文专著 经历 研究方向
发表论文(*通讯作者):
· Li F, Pendy JT, Jr., Ding JN, Peng C, Li X, Shen J, Geng X*. Exercise rehabilitation immediately following ischemic stroke exacerbates inflammatory injury. Neurological research. 2017:1-8
· Linlin Ma1,2, Longfei Guan1, Geng X*. Current AQP Research: Therapeutic Approaches to Ischemic and Hemorrhagic Stroke. Neural Regeneration Research. 2016;11(12):1918-1919. IF=0.968
· RastogiR, Geng X*, Li F, Ding Y*. NOX Activation and Interactions in Disease. Frontiers in cell neuroscience. 2016;10:301 IF=4.6
· James Yip, Geng X*, Shen J, Ding Y. Cerebral Gluconeogenesis and Diseases. Frontiers in Pharmarcology. 2016;7:521 IF=4.4
· Shen J, Geng X*, Stevenson J, Guan L, Ding Y. Fat, diet, and intracranial atherosclerosis. Environ Dis. 2016; 1: 90-4.
· Tong Y, John T. Pendy Jr, William A. Li, Du H, Zhang T, Geng X*, Ding Y*. Motor Imagery-Based Rehabilitation: Potential Neural Correlates and Clinical Application for Functional Recovery of Motor Deficits after Stroke. Aging and Disease. In press IF=3.6
· Hussain M, Datta N, Chen Z, Bashir A, Mehta T, Shweikeh F, Mazaris P, Lee N, Nouh A, Geng X*, Ding Y*. Spanning From the West to East: An Updated Review on Endovascular Treatment of Intracranial Atherosclerotic Disease. Aging and Disease. In press IF=3.6
· Huber M, Duan H, Chandra A, Li W, Wu L, Guan L, GengX*, Ding Y. Hypothermia in Stroke Therapy: Systemic versus Local Application. Hypoxia. Science, Technology and Medicine open access publisher (book) 2016
· Li F, Shi W, Zhao EY, Geng X*, Li X, Peng C, Shen J, Wang S, Ding Y*. Enhanced apoptosis from early physical exercise rehabilitation following ischemic stroke. J Neurosci Res. 2016 IF=2.69
· Shen J, Huber M, Zhao EY, Peng C, Li F, Li X, Geng X*, Ding Y*. Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (nox). Brain Res. 2016;1648:266-276 IF=2.8
· Shen J, Hafeez A, Stevenson J, Yang J, Yin C, Li F, Wang S, Du H, Ji X, Rafols JA, Geng X*, Ding Y*. Omega-3 fatty acid supplement prevents development of intracranial atherosclerosis. Neuroscience. 2016;334:226-235 IF=3.23
· Previch LE, Ma L, Wright JC, Singh S, Geng X*, Ding Y. Progress in aqp research and new developments in therapeutic approaches to ischemic and hemorrhagic stroke. Int J Mol Sci. 2016;17 IF=3.25
· Joshua C. Wright1, Ji Z, Geng X*, Ding Y. Ongoing Progress in Cleaning China’s Air: A Novel Outlook into Pollution. Environ Dis. 2016;1:43-50
· Thibodeau A, Geng X*, Previch LE, Ding Y. Pyruvate dehydrogenase complex in cerebral ischemia- reperfusion injury. Brain Circ. 2016;2: 61-6
· Shen J, Stevenson J, Geng X*, Yang J, Yin C, Li F, Wang S, Du H, Ji X, Ding Y. A new clinically relevant model for intracranial atherosclerosis in rats. Neurol Res. 2016;38:454-460 IF=1.49
· Liu K, Khan H, Geng X*, Zhang J, Ding Y. Pharmacological hypothermia: A potential for future stroke therapy? Neurol Res. 2016;38:478-490. IF=1.49
· Forreider B, Pozivilko D, Kawaji Q, Geng X*, Ding Y*. Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction. Prog Neurobiol. 2016 IF=13.17
· Geng X, Li W, Peng C, Shen J, Ji X, Du H, Ding Y. Acute Hibernation-like Neuroprotection in Severe Transient and Permanent Ischemic Stroke. Mol Neurobiol. 2016 IF=5.4
· Geng X, Ji X, Ding Y. A Dynamic Stroke Treatment Paradigm: Advances in Cerebrovascular Reperfusion and Neurorehabilitation.Current Opinions in Neurological Science. 2016; 1: 1-3 (Editorial)
· Geng X, Sy CA, Kwiecien TD, Ji X, Peng C, Rastogi R, Cai L, Du H, Brogan D, Singh S, Rafols JA, Ding Y. Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke. Brain Res. 2015;1603:65-75 IF=2.828
· Geng X, Elmadhoun O, Peng C, Ji X, Hafeez A, Liu Z, Du H, Rafols JA, Ding Y. Ethanol and normobaric oxygen: Novel approach in modulating pyruvate dehydrogenase complex after severe transient and permanent ischemic stroke. Stroke. 2015;46:492-499 IF=5.7
· Geng X, Mohammed H, Du H, Zhao L, Chen J, Su W, Ma L, Gao Z, Liu Z, Ding Y, Ji X. Comparison of Self-Expanding Stents With Distal Embolic Protection to Balloon-Expandable Stents Without a Protection Device in the Treatment of Symptomatic Vertebral Artery Origin Stenosis: A Prospective Randomized Trial.J EndovascTher.2015;22:436-444 IF=3.59
· Geng X, Fu P, Ji X, Peng C, Fredrickson V, Sy C, Meng R, Ling F, Du H, Tan X, Hüttemann M, Guthikonda M, Ding Y. Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism. Stroke. 2013;44:1418-1425 IF=5.7
· Geng X, Parmar S, Li X, Peng C, Ji X, Chakraborty T, Li WA, Du H, Tan X, Ling F, Guthikonda M, Rafols JA, Ding Y. Reduced Apoptosis by Combining Normobaric Oxygenation with Ethanol in Transient Ischemic Stroke.Brain Res. 2013;1531:17-24 IF=2.828
· Geng X, Ren C, Wang T, Fu P, Luo Y, Liu X, Yan F, Ling F, Jia J, Du H, Ji X, Ding Y. Effect of remote ischemic postconditioning on an intracerebral hemorrhage stroke model in rats. Neurol Res. 2012;34:143-148 IF=1.449
· Cai L, Geng X (Co-first author), Hussain M, Liu Z, Gao Z, Liu S, Du H, Ji X, Ding Y.Weight loss after stroke is associated with brain damage. Neurol Res. 2015;37:441-446 IF=1.449
· Liu S, Geng X (Co-first author), Forreider B, Xiao Y, Kong Q, Ding Y, Ji X. Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy. Neurol Res. 2015;37:454-460 IF=1.449
· Xie, Z., F. Chen, W. A. Li, Geng X, C. Li, X. Meng, Y. Feng, W. Liu and F. Yu. "A Review of Sleep Disorders and Melatonin." Neurol Res, (2017): 1-7.
· Li, S., A. Hafeez, F. Noorulla, Geng X, G. Shao, C. Ren, G. Lu, H. Zhao, Y. Ding and X. Ji. "Preconditioning in Neuroprotection: From Hypoxia to Ischemia." Prog Neurobiol, (2017).
· Chen J, Liu L, Zhang H, Geng X, Jiao L, Li G, Coutinho JM, Ding Y, Liebeskind DS, Ji X. Endovascular hypothermia in acute ischemic stroke: Pilot study of selective intra-arterial cold saline infusion. Stroke. 2016;47:1933-1935 IF=5.7
· Cai L, Thibodeau A, Peng C, Ji X, Rastogi R, Xin R, Singh S, Geng X, Rafols JA, Ding Y. Combination therapy of normobaric oxygen with hypothermia or ethanol modulates pyruvate dehydrogenase complex in thromboembolic cerebral ischemia. J Neurosci Res. 2016;94:749-758 IF=2.68
· Cai L, Stevenson J, Geng X, Peng C, Ji X, Xin R, Rastogi R, Sy C, Rafols JA, Ding Y. Combining normobaric oxygen with ethanol or hypothermia prevents brain damage from thromboembolic stroke via pkc-akt-nox modulation. Mol Neurobiol. 2016 IF=5.4
· Cai L, Stevenson J, Peng C, Xin R, Rastogi R, Liu K, Geng X, Gao Z, Ji X, Rafols JA, Ji Z, Ding Y. Adjuvant therapies using normobaric oxygen with hypothermia or ethanol for reducing hyperglycolysis in thromboembolic cerebral ischemia. Neuroscience. 2016;318:45-57 IF=3.35
· Carcora Y, Hussain M, Geng X, Ding Y. A review of current clinical studies leading to improved outcomes in patients treated with newer-generation thrombectomy devices. Brain Circ 2015;1:9-13
· Liu Z, Chen C, Li X, Ran YY, Xu T, Zhang Y, Geng X, Zhang Y, Du HS, Leak RK, Ji X, Hu X. Remote ischemic preconditioning-mediated neuroprotection against stroke is associated with significant alterations in peripheral immune responses. CNS neuroscience & therapeutics. 2015;22:43-52. IF=4.01
· Ji Z, Liu K, Cai L, Peng C, Xin R, Gao Z, Zhao E, Rastogi R, Han W, Rafols J. A, Geng X, Ding Y. Therapeutic effect of tpa in ischemic stroke is enhanced by its combination with normobaric oxygen and hypothermia or ethanol. Brain Res. 2015;1627:31-40 IF=2.828
· Tong Y, Forreider B, Sun X, Geng X, Zhang W, Du H, Zhang T, Ding Y. Music-supported Therapy (MST) in improving post-stoke patients’ upper-limb motor function: a randomized controlled pilot study. Neurol Res.2015;37:434-440 IF=1.449
· Kong Q, Hafeez A, Yu W, Ren C, Geng X, Xiao Y, Liu S, Zhang Y, Mao R, Zhou J, Ding Y, Ji X. Recanalization timing of carotid stenosis in experimental ischemic stroke .Neurol Res.2015;37:397-402 IF=1.449
· Hafeez A, Elmadhoun O, Peng C, Ding JY,Geng X, Guthikonda M, Ding Y. Reduced Apoptosis by Ethanol and Its Association with PKC-δ and Akt Signaling in Ischemic Stroke. Aging and Disease. 2014;5(6):366-372 IF=3.03
· Zhao B, Shang G, Chen J, Geng X, Ye X, Xu G, Wang J, Zheng J, Li H, Akbary F, Li S, Lu J, Ling F, Ji X. A more consistent intraluminal rhesus monkey model of ischemic stroke. Neural Regen Res. 2014;9:2087-2094 IF= 0.968
· Wang F, Wang Y, Geng X, Asmaro K, Peng C, Sullivan JM, Ding JY, Ji X, Ding Y. Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke. 2012;43:205-210 IF=5.7
· Ren C, Guingab-Cagmat J, Kobeissy F, Zoltewicz S, Mondello S, Gao M, Hafeez A, Li N, Geng X, Larner SF, Anagli J, Hayes RL, Ji X, Ding Y. A neuroproteomic and systems biology analysis of rat brain post intracerebral hemorrhagic stroke. Brain Res Bull. 2014;102:46-56 IF=2.974
· Ren C, Zoltewicz S, Guingab-Cagmat J, Anagli J, Gao M, Hafeez A, Li N, Cao J, Geng X, Kobeissy F, Mondello S, Larner SF, Hayes RL, Ji X, Ding Y. Different expression of ubiquitin c-terminal hydrolase-l1 and alphaii-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis. Brain Res. 2013;1540:84-91 IF=2.828
· Kochanski R, Peng C, Higashida T, Geng X, Hüttemann M, Guthikonda M, Ding Y. Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: An inhibitory effect on hyperglycolysis and nadph oxidase activation. J Neurochem.2013;44(5):1418-1425 IF=4.244
· Dornbos D, 3rd, Zwagerman N, Guo M, Ding JY, Peng C, Esmail F, Sikharam C, Geng X, Guthikonda M, Ding Y.Preischemic exercise reduces brain damage by ameliorating metabolic disorder in ischemia/reperfusion injury. J Neurosci Res. 2013;91:818-827 IF=2.729
· Ali A, Konakondla S, Zwagerman NT, Peng C, Schafer S, Ding JY, Dornbos D, 3rd, Sikharam C, Geng X, Guthikonda M, Kreipke CW, Rafols JA, Ding Y. Glycerol accumulation in edema formation following diffuse traumatic brain injury. Neurol Res.2012;34:462-468 IF=1.449
· Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011;42:1469-1472 IF=5.7